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If you're taking 2 or more blood pressure medicines but your blood pressure is still high, you may have questions about why, and what treatment options may help.
- About aldosterone
- About BAXFENDY
- Results and effectiveness
- Clinical research and approval
- Safety and side effects
- Treatment expectations
About Aldosterone
Aldosterone is a hormone made by the adrenal glands that helps control blood pressure, fluid balance, and electrolytes in the body.
It works by helping the body control how much salt and water are retained and how much potassium is released, which can influence blood pressure.
Aldosterone raises blood pressure, which means when you lower aldosterone, you can lower your blood pressure. A doctor can determine whether this may be a factor.
Yes, aldosterone is a hormone that helps regulate blood pressure, fluid balance, and electrolyte levels (like salt and potassium).
Because BAXFENDY works by directly targeting aldosterone to help lower blood pressure, your doctor may check things like potassium and sodium levels, as well as kidney function before and during treatment to help keep your body in balance.
Aldosterone is also connected to heart and blood vessel health, which is why it’s an important part of overall cardiovascular health.
Aldosterone has been recognized for many years as a hormone with a major role in blood pressure regulation.
More recently, research has focused on targeting aldosterone more directly. BAXFENDY represents this newer approach, working to help lower blood pressure by directly addressing the underlying factor.
Aldosterone levels can vary based on several factors including age, hormones, and overall health, but they are not limited to one gender or a specific stage of life.
Hormonal changes over time, including those that occur with aging, may influence how the body regulates blood pressure and hormones like aldosterone. However, elevated aldosterone can occur in both men and women, and patterns may differ from person to person.
Aldosterone testing was not required in clinical studies of BAXFENDY and is not needed to begin treatment.
Your doctor can help determine whether testing may be appropriate based on your individual medical history and overall condition.
About BAXFENDY
BAXFENDY was studied in people taking multiple blood pressure medicines and is designed to be added to existing treatment to help you lower your blood pressure.
Your doctor will review your medicines and help determine how BAXFENDY may fit into your overall treatment plan.
High blood pressure can be driven by different factors in the body, so more than one medicine is often needed to help control it.
BAXFENDY is designed to be added to your current treatment to directly target aldosterone, a hormone that can affect blood pressure.
Your healthcare provider will help determine the right combination of treatments for you.
Yes. A reduction of around 10 points in your top (systolic) blood pressure is very meaningful.
In fact, reductions like this have been linked to a lower risk of serious events like heart attack and stroke.
If your blood pressure is still high, that kind of reduction is not just a number on a chart — it can make a real difference to your long-term heart health.
BAXFENDY is a prescription medicine used along with other blood pressure medicines to treat high blood pressure (hypertension) in adults whose blood pressure is not well controlled with other medicines.
Changes to your treatment plan, including reducing or stopping other medicines, should be determined by your doctor.
It is important to continue taking your medicines as prescribed and speak with your doctor before making any changes.
Results and Effectiveness
In clinical studies, BAXFENDY lowered the top blood pressure number by nearly 10 points compared with placebo when added to other medicines.
In clinical studies, blood pressure reductions were seen in as little as 4 weeks after starting treatment with BAXFENDY, with continued effects over 12 weeks.*
*Individual results may vary.
Clinical Research and Approval
BAXFENDY has been studied in multiple clinical trials, including BaxHTN and Bax24, in adults with blood pressure that remained high despite taking 2 or more blood pressure medicines.
Across its clinical development program, BAXFENDY has been studied in clinical research involving more than 1,000 people. These studies evaluated its effects on blood pressure, as well as safety, including monitoring electrolytes and kidney function.
For more detailed information, please refer to the Prescribing Information.
BAXFENDY was approved by the U.S. Food and Drug Administration (FDA) on May 15, 2026. BAXFENDY is a prescription medicine used along with other blood pressure medicines to treat high blood pressure (hypertension) in adults whose blood pressure is not well controlled with other medicines.
Safety and Side Effects
BAXFENDY may cause side effects, including:
- Increased potassium levels in your blood (hyperkalemia). Your risk of developing hyperkalemia is increased if you are 65 years of age or older, have diabetes or kidney problems or take other medicines that can increase potassium levels. Talk to your healthcare provider before using potassium supplements or salt substitutes that contain potassium during your treatment with BAXFENDY.
- Decreased sodium levels in your blood (hyponatremia). Your risk of developing hyponatremia is increased if you already have a low sodium blood level or take medicines that can cause hyponatremia. Tell your healthcare provider right away if you have any symptoms of low sodium levels during treatment. Symptoms of low sodium levels in your blood may include unusual fatigue, dizziness, headache, shortness of breath, or confusion.
Your healthcare provider will check potassium and sodium levels in your blood before treatment with BAXFENDY and periodically during your treatment. Your healthcare provider may temporarily stop your treatment with BAXFENDY if you develop high potassium or low sodium levels in your blood.
The most common side effect is hyperkalemia. These are not all of the possible side effects of BAXFENDY. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
You may report side effects related to AstraZeneca products.
Please see Important Safety Information, Patient Information and US Full Prescribing Information.
Treatment Expectations
BAXFENDY By Your Side offers resources to help you navigate your treatment, including support with education, affordability, and getting your prescription.
Depending on your eligibility, this may include savings programs, pharmacy support, and help understanding your insurance coverage.
Coverage for BAXFENDY varies by insurance plan. Your insurer, healthcare provider, or pharmacist can help you understand your coverage.
Eligible commercially insured patients may be able to pay as little as $15 per month with the BAXFENDY Savings Card.*
You can also explore cost and affordability resources through BAXFENDY By Your Side.
*Terms and conditions apply. Eligibility and savings may vary.
You can get your BAXFENDY prescription at any retail pharmacy you choose. You can also ask your doctor to prescribe your BAXFENDY to ASPN Pharmacies for extra support with getting your medicine.
ASPN offers services like home delivery, pharmacy pickup options, auto-refill enrollment, and support with applying savings and navigating insurance.
